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The UroLift implant: mechanism behind rapid and durable relief from prostatic obstruction.
Roehrborn, Claus G; Chin, Peter T; Woo, Henry H.
Afiliação
  • Roehrborn CG; The University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Chin PT; School of Medicine, University of Wollongong & SouthCoast Urology, Wollongong, NSW, Australia.
  • Woo HH; College of Health and Medicine, Australian National University & The University of Sydney & SAN Prostate Centre of Excellence, Sydney Adventist Hospital, Wahroonga, NSW, Australia. hwoo@urologist.net.au.
Prostate Cancer Prostatic Dis ; 25(1): 79-85, 2022 03.
Article em En | MEDLINE | ID: mdl-34363010
ABSTRACT

BACKGROUND:

Benign prostatic hyperplasia (BPH) is an affliction of the aging male population that contributes to bothersome and disruptive lower urinary tract symptoms (LUTS). The UroLift® implant has been developed as a mechanical means of widening the prostatic urethra and providing relief from lower urinary tract symptoms (LUTS) through a minimally invasive procedure.

METHODS:

In the current study, we utilize histological results from canine tissue, resected tissue from human subjects treated with the UroLift System and post-market surveillance data collected by the manufacturer in order to elucidate the long-term biological mechanism of action of the UroLift implant.

RESULTS:

The delivery of the implant causes tissue compression, likely resulting in focal ischemia that causes observed local atrophy and minimal-mild chronic inflammation that ultimately remodels tissue to produce a widened prostatic urethra.

CONCLUSIONS:

These studies reveal the lack of impact the device has on systemic tissue, providing evidence that the UroLift System is benign and biocompatible, and offering histologic explanation for the clinically observed durability.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hiperplasia Prostática / Neoplasias da Próstata / Sintomas do Trato Urinário Inferior Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hiperplasia Prostática / Neoplasias da Próstata / Sintomas do Trato Urinário Inferior Idioma: En Ano de publicação: 2022 Tipo de documento: Article