The activation effects of fucoidan from sea cucumber Stichopus chloronotus on RAW264.7 cells via TLR2/4-NF-&#954;B pathway and its structure-activity relationship.

Jiang, Shuxin; Yin, Huanan; Li, Rui; Shi, Weiwei; Mou, Jiaojiao; Yang, Jie

The activation effects of fucoidan from sea cucumber Stichopus chloronotus on RAW264.7 cells via TLR2/4-NF-κB pathway and its structure-activity relationship.

Jiang, Shuxin; Yin, Huanan; Li, Rui; Shi, Weiwei; Mou, Jiaojiao; Yang, Jie.

Afiliação

Jiang S; School of Pharmacy, Weifang Medical University, Weifang 261053, Shandong, China.
Yin H; School of Pharmacy, Weifang Medical University, Weifang 261053, Shandong, China.
Li R; School of Pharmacy, Weifang Medical University, Weifang 261053, Shandong, China.
Shi W; School of Pharmacy, Weifang Medical University, Weifang 261053, Shandong, China.
Mou J; School of Public Health, Weifang Medical University, Weifang 261053, Shandong, China. Electronic address: moujiaojiao@wfmc.edu.cn.
Yang J; School of Pharmacy, Weifang Medical University, Weifang 261053, Shandong, China; Innovative Drug Research and Development Center, Weifang Medical University, Weifang 261053, Shandong, China. Electronic address: yangjie@wfmc.edu.cn.

Carbohydr Polym ; 270: 118353, 2021 Oct 15.

Article em En | MEDLINE | ID: mdl-34364600

Assuntos

Adjuvantes Imunológicos/farmacologia; NF-kappa B/metabolismo; Polissacarídeos/farmacologia; Stichopus/química; Receptor 2 Toll-Like/metabolismo; Adjuvantes Imunológicos/química; Animais; Sobrevivência Celular/efeitos dos fármacos; China; Humanos; Interleucina-10/metabolismo; Interleucina-6/metabolismo; Camundongos; Peso Molecular; Óxido Nítrico/metabolismo; Polissacarídeos/química; Células RAW 264.7; Pepinos-do-Mar/química; Transdução de Sinais/efeitos dos fármacos; Relação Estrutura-Atividade; Receptor 4 Toll-Like/metabolismo; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

Fucoidan; Raw264.7 cells; Stichopus chloronotus; Structure-activity relationship; TLR2/4-NF-κB pathway

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polissacarídeos / Adjuvantes Imunológicos / NF-kappa B / Stichopus / Receptor 2 Toll-Like Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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