3D printable self-healing hyaluronic acid/chitosan polycomplex hydrogels with drug release capability.
Int J Biol Macromol
; 188: 820-832, 2021 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-34371046
ABSTRACT
Multifunctional printable biomaterials are at the base of advanced biomedical applications. Chitosan (CHI) and hyaluronic acid (HA) allow the development of polycomplex hydrogels with tailorable properties, including self-healing and controlled drug release. This work correlates and optimizes the mucoadhesive, swelling, biodegradation, mechanical and rheological properties of HA/CHI polycomplex hydrogels with synthesis parameters such as polysaccharide content and complexation time, according to the interaction forces established between both polyelectrolytes. Related to these dynamic forces, the self-healing ability of the hydrogels was investigated together with the potential of the HA/CHI polycomplex hydrogels for 3D printing. Finally, their capability to modulate and promote controlled release of a variety of drugs (anionic and anti-inflammatory sodium diclofenac and the neutral antibiotic rifampicin) was demonstrated. Thus, the reported tunable properties, self-repair ability, printability and drug release properties, demonstrate the suitability of HA/CHI hydrogels for advanced biomedical applications.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hidrogéis
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Quitosana
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Liberação Controlada de Fármacos
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Impressão Tridimensional
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Ácido Hialurônico
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article