The application of umbilical cord-derived MSCs in cardiovascular diseases.
J Cell Mol Med
; 25(17): 8103-8114, 2021 09.
Article
em En
| MEDLINE
| ID: mdl-34378345
ABSTRACT
Transplantation of stem cells is a promising, emerging treatment for cardiovascular diseases in the modern era. Mesenchymal stem cells (MSCs) derived from the umbilical cord are one of the most promising cell sources because of their capacity for differentiation into cardiomyocytes, endothelial cells and vascular smooth muscle cells in vitro/in vivo. In addition, umbilical cord-derived MSCs (UC-MSCs) secrete many effective molecules regulating apoptosis, fibrosis and neovascularization. Another important and specific characteristic of UC-MSCs is their low immunogenicity and immunomodulatory properties. However, the application of UC-MSCs still faces some challenges, such as low survivability and tissue retention in a harmful disease environment. Gene engineering and pharmacological studies have been implemented to overcome these difficulties. In this review, we summarize the differentiation ability, secretion function, immunoregulatory properties and preclinical/clinical studies of UC-MSCs, highlighting the advantages of UC-MSCs for the treatment of cardiovascular diseases.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cordão Umbilical
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Doenças Cardiovasculares
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Transplante de Células-Tronco Mesenquimais
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Células-Tronco Mesenquimais
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article