Self-assembled fluorescent hybrid nanoparticles-mediated collaborative lncRNA CCAT1 silencing and curcumin delivery for synchronous colorectal cancer theranostics.

Jia, Fan; Li, Yunhao; Deng, Xiongwei; Wang, Xuan; Cui, Xinyue; Lu, Jianqing; Pan, Zian; Wu, Yan

Jia, Fan; Li, Yunhao; Deng, Xiongwei; Wang, Xuan; Cui, Xinyue; Lu, Jianqing; Pan, Zian; Wu, Yan.

Afiliação

Jia F; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China.
Li Y; University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
Deng X; Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, People's Republic of China.
Wang X; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China. dengxiongwei.happy@163.com.
Cui X; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China.
Lu J; University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
Pan Z; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China.
Wu Y; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China. lujq@nanoctr.cn.

J Nanobiotechnology ; 19(1): 238, 2021 Aug 11.

Article em En | MEDLINE | ID: mdl-34380471

Assuntos

Curcumina/farmacologia; Nanopartículas/química; RNA Longo não Codificante/genética; RNA Longo não Codificante/farmacologia; Animais; Apoptose/efeitos dos fármacos; Neoplasias do Colo/tratamento farmacológico; Neoplasias do Colo/genética; Combinação de Medicamentos; Sistemas de Liberação de Medicamentos/métodos; Feminino; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Células HT29; Humanos; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Polímeros; Medicina de Precisão; Interferência de RNA; RNA Longo não Codificante/química; RNA Interferente Pequeno/genética

Palavras-chave

Co-delivery; Combinational therapy; Curcumin; LncRNA CCAT1; RNAi; Theranostic nanoparticles

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Curcumina / Nanopartículas / RNA Longo não Codificante Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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