A broadly active fucosyltransferase LmjFUT1 whose mitochondrial localization and activity are essential in parasitic <i>Leishmania</i>.

Guo, Hongjie; Damerow, Sebastian; Penha, Luciana; Menzies, Stefanie; Polanco, Gloria; Zegzouti, Hicham; Ferguson, Michael A J; Beverley, Stephen M

A broadly active fucosyltransferase LmjFUT1 whose mitochondrial localization and activity are essential in parasitic Leishmania.

Guo, Hongjie; Damerow, Sebastian; Penha, Luciana; Menzies, Stefanie; Polanco, Gloria; Zegzouti, Hicham; Ferguson, Michael A J; Beverley, Stephen M.

Afiliação

Guo H; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Damerow S; Division of Biological Chemistry and Drug Discovery, Wellcome Trust Biocentre, College of Life Science, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom.
Penha L; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Menzies S; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Polanco G; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Zegzouti H; R&D Department, Promega Corporation, Madison, WI 53711.
Ferguson MAJ; Division of Biological Chemistry and Drug Discovery, Wellcome Trust Biocentre, College of Life Science, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom.
Beverley SM; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110; stephen.beverley@wustl.edu.

Proc Natl Acad Sci U S A ; 118(33)2021 08 17.

Article em En | MEDLINE | ID: mdl-34385330

Assuntos

Fucosiltransferases/metabolismo; Regulação Enzimológica da Expressão Gênica/fisiologia; Leishmania major/metabolismo; Mitocôndrias/enzimologia; Proteínas de Protozoários/metabolismo; Sequência de Aminoácidos; Meios de Cultura; Fucosiltransferases/genética; Mutação; Plasmídeos; Transporte Proteico; Proteínas de Protozoários/genética; Galactosídeo 2-alfa-L-Fucosiltransferase

Palavras-chave

chemotherapy; fucose; glycobiology; glycosyltransferase; trypanosomatid protozoan parasites

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulação Enzimológica da Expressão Gênica / Proteínas de Protozoários / Leishmania major / Fucosiltransferases / Mitocôndrias Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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