Clinical and microbiological profile of adult inpatients with community acquired pneumonia in Ilorin, North Central, Nigeria.
Afr Health Sci
; 20(4): 1655-1668, 2020 Dec.
Article
em En
| MEDLINE
| ID: mdl-34394226
ABSTRACT
BACKGROUND:
The optimal management of community acquired pneumonia (CAP) depends on the clinical and microbiological profile in the locality.OBJECTIVES:
To determine the clinical and microbiological profile of patients admitted with CAP in Ilorin, Nigeria.METHODS:
One hundred and two consenting consecutively selected patients with clinical and radiologic confirmation of CAP were recruited in 12 months. The socio-demographic, physical examination and laboratory/radiologic parameters were documented in a questionnaire. Microbiological evaluation of their sputum was done and blood samples were taken for complete blood count, culture, serum urea and serological evaluation for atypical bacteria and some viral pathogens.RESULTS:
CAP constituted 5.9% of the total medical admissions during the one-year study period. The mean age of the patients was 49 ± 22 years with the largest frequency in those aged 65 years and above. The commonest symptoms were shortness of breath (96.1%) and cough (94.1%), with a median duration of 3 days from symptom onset to admission. Systemic hypertension was the commonest comorbid illness (25/102; 24.5%). Klebsiella pneumoniae was the predominant pathogen isolated (20/102; 28.1%). The susceptible antibiotics were Imipenem, Ceftazidime and Ceftriaxone. Intra-hospital mortality was 17.6%. CURB - 65 score of ≥ 2 and the presence of complications of CAP were the independent predictors of mortality.CONCLUSION:
CAP constitutes a significant disease burden in Ilorin, Nigeria. Typical bacteria accounted for over half of the pathogens isolated from the patients with gram negative agents predominating. This highlights a possible shift in the microbiological profile which could guide empirical treatment.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Pneumonia Viral
/
Infecções Comunitárias Adquiridas
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Pneumonia Bacteriana
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article