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Gonococcal Pelvic Inflammatory Disease: Placing Mechanistic Insights Into the Context of Clinical and Epidemiological Observations.
Xu, Stacey X; Gray-Owen, Scott D.
Afiliação
  • Xu SX; Department of Molecular Genetics, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
  • Gray-Owen SD; Department of Molecular Genetics, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
J Infect Dis ; 224(12 Suppl 2): S56-S63, 2021 08 16.
Article em En | MEDLINE | ID: mdl-34396410
While infection by Neisseria gonorrhoeae is often asymptomatic in women, undetected infections can ascend into the upper genital tract to elicit an inflammatory response that manifests as pelvic inflammatory disease, with the outcomes depending on the intensity and duration of inflammation and whether it is localized to the endometrial, fallopian tube, ovarian, and/or other tissues. This review examines the contribution of N. gonorrhoeae versus other potential causes of pelvic inflammatory disease by considering new insights gained through molecular, immunological, and microbiome-based analyses, and the current epidemiological burden of infection, with an aim to highlighting key areas for future study.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por Chlamydia / Gonorreia / Doença Inflamatória Pélvica / Neisseria gonorrhoeae Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por Chlamydia / Gonorreia / Doença Inflamatória Pélvica / Neisseria gonorrhoeae Idioma: En Ano de publicação: 2021 Tipo de documento: Article