Formaldehyde-Crosslinked Nontoxic Aß Monomers to Form Toxic Aß Dimers and Aggregates: Pathogenicity and Therapeutic Perspectives.

Zhao, Hang; Huang, Xuerong; Tong, Zhiqian

Zhao, Hang; Huang, Xuerong; Tong, Zhiqian.

Afiliação

Zhao H; Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, School of Mental Health, Wenzhou Medical University, Wenzhou, 325035, China.
Huang X; Wenzhou Medical University Affiliated Hospital 3, Department of Neurology, Wenzhou, 325200, China.
Tong Z; Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, School of Mental Health, Wenzhou Medical University, Wenzhou, 325035, China.

ChemMedChem ; 16(22): 3376-3390, 2021 11 19.

Article em En | MEDLINE | ID: mdl-34396700

Assuntos

Doença de Alzheimer/tratamento farmacológico; Peptídeos beta-Amiloides/antagonistas & inibidores; Formaldeído/farmacologia; Fármacos Neuroprotetores/farmacologia; Doença de Alzheimer/metabolismo; Doença de Alzheimer/patologia; Peptídeos beta-Amiloides/metabolismo; Formaldeído/química; Humanos; Fármacos Neuroprotetores/química; Agregados Proteicos/efeitos dos fármacos

Palavras-chave

Aß dimer; Aß monomer; blood-brain barrier (BBB); extracellular space (ECS); formaldehyde (FA)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos beta-Amiloides / Fármacos Neuroprotetores / Doença de Alzheimer / Formaldeído Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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