Inhibition of HDACs (Histone Deacetylases) Ameliorates High-Fat Diet-Induced Hypertension Through Restoration of the MsrA (Methionine Sulfoxide Reductase A)/Hydrogen Sulfide Axis.

Jung, Jin Ki; Yoon, Ga-Eun; Jang, GiBong; Park, Kwon Moo; Kim, InKyeom; Kim, Jee In

Jung, Jin Ki; Yoon, Ga-Eun; Jang, GiBong; Park, Kwon Moo; Kim, InKyeom; Kim, Jee In.

Afiliação

Jung JK; Department of Molecular Medicine and Medical Research Center, Keimyung University School of Medicine, Daegu 42601, Republic of Korea (J.K.J., G.-E.Y., J.I.K.).
Yoon GE; Department of Molecular Medicine and Medical Research Center, Keimyung University School of Medicine, Daegu 42601, Republic of Korea (J.K.J., G.-E.Y., J.I.K.).
Jang G; Department of Anatomy and BK21 Plus (G.J., K.M.P.), School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.
Park KM; Department of Anatomy and BK21 Plus (G.J., K.M.P.), School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.
Kim I; Department of Pharmacology (I.K.), School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.
Kim JI; Department of Molecular Medicine and Medical Research Center, Keimyung University School of Medicine, Daegu 42601, Republic of Korea (J.K.J., G.-E.Y., J.I.K.).

Hypertension ; 78(4): 1103-1115, 2021 09.

Article em En | MEDLINE | ID: mdl-34397279

ABSTRACT

ABSTRACT

[Figure see text].

Assuntos

Dieta Hiperlipídica; Inibidores de Histona Desacetilases/farmacologia; Sulfeto de Hidrogênio/metabolismo; Ácidos Hidroxâmicos/farmacologia; Hipertensão/tratamento farmacológico; Metionina Sulfóxido Redutases/fisiologia; Naftalenos/farmacologia; Animais; Inibidores de Histona Desacetilases/uso terapêutico; Histonas/metabolismo; Hipertensão/etiologia; Masculino; Metionina Sulfóxido Redutases/genética; Camundongos; Camundongos Endogâmicos C57BL; Músculo Liso Vascular/citologia; Miócitos de Músculo Liso/fisiologia; Estresse Oxidativo/efeitos dos fármacos; Regiões Promotoras Genéticas; Vasoconstrição

Palavras-chave

high fat diet; histone deacetylases; hydrogen sulfide; hypertension; methionine sulfoxide reductase; vasoconstriction

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Metionina Sulfóxido Redutases / Inibidores de Histona Desacetilases / Dieta Hiperlipídica / Sulfeto de Hidrogênio / Ácidos Hidroxâmicos / Hipertensão / Naftalenos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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