Cardiac pathologies in mouse loss of imprinting models are due to misexpression of H19 long noncoding RNA.

Park, Ki-Sun; Rahat, Beenish; Lee, Hyung Chul; Yu, Zu-Xi; Noeker, Jacob; Mitra, Apratim; Kean, Connor M; Knutsen, Russell H; Springer, Danielle; Gebert, Claudia M; Kozel, Beth A; Pfeifer, Karl

Park, Ki-Sun; Rahat, Beenish; Lee, Hyung Chul; Yu, Zu-Xi; Noeker, Jacob; Mitra, Apratim; Kean, Connor M; Knutsen, Russell H; Springer, Danielle; Gebert, Claudia M; Kozel, Beth A; Pfeifer, Karl.

Afiliação

Park KS; Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.
Rahat B; Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.
Lee HC; Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.
Yu ZX; Pathology Core, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, United States.
Noeker J; Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.
Mitra A; Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.
Kean CM; Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.
Knutsen RH; Laboratory of Vascular and Matrix Genetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, United States.
Springer D; Murine Phenotyping Core, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, United States.
Gebert CM; Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.
Kozel BA; Laboratory of Vascular and Matrix Genetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, United States.
Pfeifer K; Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.

Elife ; 102021 08 17.

Article em En | MEDLINE | ID: mdl-34402430

Assuntos

Sistema Cardiovascular/metabolismo; Sistema Cardiovascular/patologia; RNA Longo não Codificante/genética; RNA Longo não Codificante/metabolismo; Animais; Síndrome de Beckwith-Wiedemann/genética; Síndrome de Beckwith-Wiedemann/metabolismo; Cardiomiopatias/metabolismo; Cardiomiopatias/patologia; Diferenciação Celular; Modelos Animais de Doenças; Células Endoteliais/metabolismo; Células Endoteliais/patologia; Fator de Crescimento Insulin-Like II/genética; Fator de Crescimento Insulin-Like II/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; MicroRNAs/metabolismo; Miócitos Cardíacos/metabolismo; Miócitos Cardíacos/patologia; Fenótipo; Transdução de Sinais

Palavras-chave

H19 lncRNA; IGF2; beckwith wiedemann syndrome; developmental biology; epigenetics; genetics; genomic imprinting; genomics; heart; mouse

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistema Cardiovascular / RNA Longo não Codificante Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistema Cardiovascular / RNA Longo não Codificante Idioma: En Ano de publicação: 2021 Tipo de documento: Article