Phage Diversity in the Human Gut Microbiome: a Taxonomist's Perspective.
mSystems
; 6(4): e0079921, 2021 Aug 31.
Article
em En
| MEDLINE
| ID: mdl-34402650
ABSTRACT
Bacteriophages (phages) have been known for over a century, but only in the last 2 decades have we really come to appreciate how abundant and diverse they are. With that realization, research groups across the globe have shown the importance of phage-based processes in a myriad of environments, including the global oceans and soils, and as part of the human microbiome. Through advances in sequencing technology, genomics, and bioinformatics, we know that the morphological diversity of bacteriophages originally used for taxonomy is eclipsed by their genomic diversity. Because we currently do not have a complete taxonomic framework or naming scheme to describe this diversity, crucial information from virome and microbiome studies is being lost. In this commentary, I will discuss recent advances in taxonomy and its importance for studies of the microbiome with examples of the human gut phageome and make recommendations for future analyses.
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MEDLINE
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En
Ano de publicação:
2021
Tipo de documento:
Article