Biomimetic Domino Knoevenagel/Cycloisomerization Strategy for the Synthesis of Citridone A and Derivatives.
J Org Chem
; 86(17): 12226-12236, 2021 09 03.
Article
em En
| MEDLINE
| ID: mdl-34410723
ABSTRACT
Studies on Knoevenagel condensations between conjugated dienals and 4-hydroxy-2-pyridone/quinolone-type 1,3-dicarbonyl equivalents led to the development of a simple one-pot strategy to access citridone A and related synthetic cyclopenta[b]furopyridones/quinolones. The present work highlights the power of domino cascades in the synthesis of natural product frameworks and may help promote future studies on this promising new class of pyridone alkaloids.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Biomimética
/
Alcaloides
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article