The number 13 of the family: a proliferation inducing ligand.
Curr Opin Immunol
; 71: 132-137, 2021 08.
Article
em En
| MEDLINE
| ID: mdl-34411773
ABSTRACT
The TNF superfamily member a proliferation inducing ligand (APRIL, TNFSF13) plays a late role in humoral immunity at the level of antibody-producing plasmocytes. The recent characterization of the first immunodeficient patient with an inactivating mutation in the APRIL gene provided the last piece of functional data lacking in the human system. Based on this function, APRIL has been considered as a valuable target to dampen unwanted antibody production. After reviewing the late data acquired on the physiological function of APRIL in humoral immunity, we will here review the state of the art regarding APRIL targeting in autoimmune diseases.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Membro 13 da Superfamília de Ligantes de Fatores de Necrose Tumoral
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article