Granzyme A Produced by Î³<sub>9</sub>Î´<sub>2</sub> T Cells Activates ER Stress Responses and ATP Production, and Protects Against Intracellular Mycobacterial Replication Independent of Enzymatic Activity.

Rasi, Valerio; Wood, David C; Eickhoff, Christopher S; Xia, Mei; Pozzi, Nicola; Edwards, Rachel L; Walch, Michael; Bovenschen, Niels; Hoft, Daniel F

Granzyme A Produced by Î³₉Î´₂ T Cells Activates ER Stress Responses and ATP Production, and Protects Against Intracellular Mycobacterial Replication Independent of Enzymatic Activity.

Rasi, Valerio; Wood, David C; Eickhoff, Christopher S; Xia, Mei; Pozzi, Nicola; Edwards, Rachel L; Walch, Michael; Bovenschen, Niels; Hoft, Daniel F.

Afiliação

Rasi V; Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, MO, United States.
Wood DC; Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, MO, United States.
Eickhoff CS; Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO, United States.
Xia M; Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, MO, United States.
Pozzi N; Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, MO, United States.
Edwards RL; Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO, United States.
Walch M; Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, MO, United States.
Bovenschen N; Anatomy Unit, Department of Oncology, Microbiology and Immunology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
Hoft DF; Department of Pathology, University Medical Center Utrecht, Utrecht, Netherlands.

Front Immunol ; 12: 712678, 2021.

Article em En | MEDLINE | ID: mdl-34413857

Assuntos

Trifosfato de Adenosina/biossíntese; Estresse do Retículo Endoplasmático/imunologia; Granzimas/fisiologia; Monócitos/microbiologia; Mycobacterium bovis/fisiologia; Subpopulações de Linfócitos T/imunologia; Western Blotting; Divisão Celular; Granzimas/biossíntese; Granzimas/genética; Granzimas/farmacologia; Células HEK293; Humanos; Células T de Memória/imunologia; Células T de Memória/metabolismo; Proteoma; Receptores de Antígenos de Linfócitos T gama-delta/análise; Proteínas Recombinantes/farmacologia; Subpopulações de Linfócitos T/metabolismo; Eletroforese em Gel Diferencial Bidimensional

Palavras-chave

2D-DIGE; ATP production; BCG; ER stress response; GZMA; Granzyme A; Mycobacterium tuberculosis; human monocyte

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Monócitos / Trifosfato de Adenosina / Subpopulações de Linfócitos T / Granzimas / Estresse do Retículo Endoplasmático / Mycobacterium bovis Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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