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Antitubercular metabolites from the marine-derived fungus strain Aspergillus fumigatus MF029.
Song, Zhijun; Liu, Yu; Gao, Jieyu; Hu, Jiansen; He, Hongtao; Dai, Shengwang; Wang, Luoqiang; Dai, Huanqin; Zhang, Lixin; Song, Fuhang.
Afiliação
  • Song Z; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
  • Liu Y; University of Chinese Academy of Sciences, Beijing, China.
  • Gao J; China Astronaut Research and Training Center, Beijing, China.
  • Hu J; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
  • He H; School of Food and biological Engineering, Hefei University of Technology, Hefei, China.
  • Dai S; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
  • Wang L; University of Chinese Academy of Sciences, Beijing, China.
  • Dai H; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
  • Zhang L; University of Chinese Academy of Sciences, Beijing, China.
  • Song F; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Nat Prod Res ; 35(16): 2647-2654, 2021 Aug.
Article em En | MEDLINE | ID: mdl-34414849
ABSTRACT
During the systematic screening of bioactive compounds from our marine natural product library, crude extract of the marine-derived fungus strain Aspergillus fumigatus MF029 exhibited moderate bioactivities against Bacillus subtilis, Staphylococcus aureus, methicillin-resistant S. aureus, and Mycobacterium bovis bacillus Calmette-Guérin (BCG). Further chemical investigation resulted in the identification of two new compounds, chaetominine A (1) and sphingofungin I (2), together with four known compounds, emodin (3), chaetominine (4), sphingofungin D (5) and trypacidin (6). Trypacidin displayed potential antitubercular activity with MIC value of 1.25 µg/mL.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aspergillus fumigatus / Produtos Biológicos / Antituberculosos Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aspergillus fumigatus / Produtos Biológicos / Antituberculosos Idioma: En Ano de publicação: 2021 Tipo de documento: Article