Your browser doesn't support javascript.
loading
Antifibrotic drugs in lung transplantation and chronic lung allograft dysfunction: a review.
Bos, Saskia; De Sadeleer, Laurens J; Vanstapel, Arno; Beeckmans, Hanne; Sacreas, Annelore; Yserbyt, Jonas; Wuyts, Wim A; Vos, Robin.
Afiliação
  • Bos S; Dept of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium saskia.bos@uzleuven.be.
  • De Sadeleer LJ; Dept of Respiratory Diseases, Ziekenhuis Oost-Limburg, Genk, Belgium.
  • Vanstapel A; Dept of CHROMETA, Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), KU Leuven, Leuven, Belgium.
  • Beeckmans H; Dept of CHROMETA, Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), KU Leuven, Leuven, Belgium.
  • Sacreas A; Dept of Internal Medicine, University Hospitals Leuven, Leuven, Belgium.
  • Yserbyt J; Dept of CHROMETA, Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), KU Leuven, Leuven, Belgium.
  • Wuyts WA; Dept of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium.
  • Vos R; Dept of CHROMETA, Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), KU Leuven, Leuven, Belgium.
Eur Respir Rev ; 30(160)2021 Jun 30.
Article em En | MEDLINE | ID: mdl-34415849
ABSTRACT
This review aims to provide an overview of pre-transplant antifibrotic therapy on peri-transplant outcomes and to address the possible role of antifibrotics in lung transplant recipients with chronic lung allograft dysfunction.Lung transplantation is an established treatment modality for patients with various end-stage lung diseases, of which idiopathic pulmonary fibrosis and other progressive fibrosing interstitial lung diseases are growing indications. Theoretically, widespread use of antifibrotics prior to lung transplantation may increase the risk of bronchial anastomotic complications and impaired wound healing.Long-term graft and patient survival are still hampered by development of chronic lung allograft dysfunction, on which antifibrotics may have a beneficial impact.Antifibrotics until the moment of lung transplantation proved to be safe, without increasing peri-transplant complications. Currently, best practice is to continue antifibrotics until time of transplantation. In a large multicentre randomised trial, pirfenidone did not appear to have a beneficial effect on lung function decline in established bronchiolitis obliterans syndrome. The results of antifibrotic therapy in restrictive allograft syndrome are eagerly awaited, but nonrandomised data from small case reports/series are promising.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transplante de Pulmão / Fibrose Pulmonar Idiopática / Antifibróticos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transplante de Pulmão / Fibrose Pulmonar Idiopática / Antifibróticos Idioma: En Ano de publicação: 2021 Tipo de documento: Article