Microscale dynamics of electrophysiological markers of epilepsy.
Clin Neurophysiol
; 132(11): 2916-2931, 2021 11.
Article
em En
| MEDLINE
| ID: mdl-34419344
ABSTRACT
OBJECTIVE:
Interictal discharges (IIDs) and high frequency oscillations (HFOs) are established neurophysiologic biomarkers of epilepsy, while microseizures are less well studied. We used custom poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOTPSS) microelectrodes to better understand these markers' microscale spatial dynamics.METHODS:
Electrodes with spatial resolution down to 50 µm were used to record intraoperatively in 30 subjects. IIDs' degree of spread and spatiotemporal paths were generated by peak-tracking followed by clustering. Repeating HFO patterns were delineated by clustering similar time windows. Multi-unit activity (MUA) was analyzed in relation to IID and HFO timing.RESULTS:
We detected IIDs encompassing the entire array in 93% of subjects, while localized IIDs, observed across < 50% of channels, were seen in 53%. IIDs traveled along specific paths. HFOs appeared in small, repeated spatiotemporal patterns. Finally, we identified microseizure events that spanned 50-100 µm. HFOs covaried with MUA, but not with IIDs.CONCLUSIONS:
Overall, these data suggest that irritable cortex micro-domains may form part of an underlying pathologic architecture which could contribute to the seizure network.SIGNIFICANCE:
These results, supporting the possibility that epileptogenic cortex comprises a mosaic of irritable domains, suggests that microscale approaches might be an important perspective in devising novel seizure control therapies.Palavras-chave
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Base de dados:
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Assunto principal:
Encéfalo
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Mapeamento Encefálico
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Eletroencefalografia
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Epilepsia
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Monitorização Neurofisiológica Intraoperatória
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Microeletrodos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article