Benzo[a]pyrene aggravates atopic dermatitis-like skin lesions in mice.
Hum Exp Toxicol
; 40(12_suppl): S269-S277, 2021 Dec.
Article
em En
| MEDLINE
| ID: mdl-34424081
ABSTRACT
Background:
Benzo[a]pyrene (BaP) affects the immune system and causes mutagenic and carcinogenic effects.Purpose:
We aimed to evaluate the effects of systemic exposure to BaP on mite allergen-induced atopic dermatitis (AD)-like skin lesions in mice.Methods:
Mite allergen (Dermatophagoides pteronyssinus; Dp) was injected intradermally into the right ears of NC/Nga male mice on eight occasions every 2-3 days. Benzo[a]pyrene was administered intraperitoneally in the equivalent doses of 0, 2, 20, 200, or 2000 µg/kg/day, once a week on four occasions.Results:
AD-like skin inflammation related to mite allergen worsened by BaP exposure at 2, 20 µg/kg/day doses; this was in parallel with eosinophil and mast cell infiltration and mast cell degranulation. A trend was also observed toward increased proinflammatory molecule expression, including macrophage inflammatory protein-1 alpha, interleukin (IL)-4, IL-13, and IL-18, in the ear tissue. However, 200 or 2000 µg/kg/day BaP attenuated the enhancing effects. In the regional lymph nodes, 2 µg/kg/day BaP with Dp enhanced antigen-presenting cell and T cell activation compared with Dp alone.Conclusions:
This suggests that BaP exposure can aggravate Dp-induced AD-like skin lesions through TH2-biased responses in the inflamed sites and the activation of regional lymph nodes. Therefore, BaP may be responsible for the recent increase in AD incidence.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Benzo(a)pireno
/
Antígenos de Dermatophagoides
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Dermatite Atópica
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article