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Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors.
Calandrini, Camilla; van Hooff, Sander R; Paassen, Irene; Ayyildiz, Dilara; Derakhshan, Sepide; Dolman, M Emmy M; Langenberg, Karin P S; van de Ven, Marieke; de Heus, Cecilia; Liv, Nalan; Kool, Marcel; de Krijger, Ronald R; Tytgat, Godelieve A M; van den Heuvel-Eibrink, Marry M; Molenaar, Jan J; Drost, Jarno.
Afiliação
  • Calandrini C; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Oncode Institute, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands.
  • van Hooff SR; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands.
  • Paassen I; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Oncode Institute, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands.
  • Ayyildiz D; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Oncode Institute, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands.
  • Derakhshan S; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Oncode Institute, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands.
  • Dolman MEM; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands.
  • Langenberg KPS; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands.
  • van de Ven M; Preclinical Intervention Unit of the Mouse Clinic for Cancer and Ageing (MCCA), NKI, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.
  • de Heus C; Cell Biology, Center for Molecular Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.
  • Liv N; Cell Biology, Center for Molecular Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.
  • Kool M; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Hopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Research Center DKFZ and German Cancer Consortium DKTK, 69120 Heidelberg, Germany.
  • de Krijger RR; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; University Medical Center, Department of Pathology, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.
  • Tytgat GAM; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands.
  • van den Heuvel-Eibrink MM; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands.
  • Molenaar JJ; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands.
  • Drost J; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Oncode Institute, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands. Electronic address: j.drost@prinsesmaximacentrum.nl.
Cell Rep ; 36(8): 109568, 2021 08 24.
Article em En | MEDLINE | ID: mdl-34433038
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Organoides / Regulação Neoplásica da Expressão Gênica / Tumor Rabdoide / Ciclopentanos / Resposta a Proteínas não Dobradas Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Organoides / Regulação Neoplásica da Expressão Gênica / Tumor Rabdoide / Ciclopentanos / Resposta a Proteínas não Dobradas Idioma: En Ano de publicação: 2021 Tipo de documento: Article