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Small molecule inhibition of ATM kinase increases CRISPR-Cas9 1-bp insertion frequency.
Bermudez-Cabrera, Heysol C; Culbertson, Sannie; Barkal, Sammy; Holmes, Benjamin; Shen, Max W; Zhang, Sophia; Gifford, David K; Sherwood, Richard I.
Afiliação
  • Bermudez-Cabrera HC; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Culbertson S; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Barkal S; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Holmes B; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Shen MW; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Zhang S; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Gifford DK; Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Sherwood RI; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Nat Commun ; 12(1): 5111, 2021 08 25.
Article em En | MEDLINE | ID: mdl-34433825
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tioxantenos / Morfolinas / Mutagênese Insercional / Inibidores de Proteínas Quinases / Proteínas Mutadas de Ataxia Telangiectasia / Sistemas CRISPR-Cas Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tioxantenos / Morfolinas / Mutagênese Insercional / Inibidores de Proteínas Quinases / Proteínas Mutadas de Ataxia Telangiectasia / Sistemas CRISPR-Cas Idioma: En Ano de publicação: 2021 Tipo de documento: Article