Deep eutectic solvent synthesis of iron vanadate-decorated sulfur-doped carbon nanofiber nanocomposite: electrochemical sensing tool for doxorubicin.
Mikrochim Acta
; 188(9): 303, 2021 Aug 25.
Article
em En
| MEDLINE
| ID: mdl-34435234
ABSTRACT
Detection of anticancer drug (doxorubicin) using an electrochemical sensor is developed based on a transition metal vanadate's related carbon composite material. With an environmentally friendly process, we have synthesized a metal oxide composite of iron vanadate nanoparticle assembled with sulfur-doped carbon nanofiber (FeV/SCNF). The FeV/SCNF composite was characterized using XRD, TEM, FESEM with elemental mapping, XPS and EDS. In contrast to other electrodes reported in the literature, a much-improved electrochemical efficiency is shown by FeV/SCNF composite modified electrodes. Amperometric technique has been employed at 0.25 V (vs. Ag/AgCl) for the sensitive detection of DOX within a wide range of 20 nM-542.5 µM and it possesses enhanced selectivity in presence of common interferents. The modified electrochemical sensors show high sensitivity of 46.041 µA µM-1 cm-2. The newly developed sensor could be used for the determination of doxorubicin in both blood serum and drug formulations with acceptable results, suggesting its feasibility for real-time applications.
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Base de dados:
MEDLINE
Assunto principal:
Doxorrubicina
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Nanocompostos
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Nanofibras
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Antineoplásicos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article