α,α-Difluorophosphonohydroxamic Acid Derivatives among the Best Antibacterial Fosmidomycin Analogues.
Molecules
; 26(16)2021 Aug 23.
Article
em En
| MEDLINE
| ID: mdl-34443699
ABSTRACT
Three α,α-difluorophosphonate derivatives of fosmidomycin were synthesized from diethyl 1,1-difluorobut-3-enylphosphonate and were evaluated on Escherichia coli. Two of them are among the best 1-deoxy-d-xylulose 5-phosphate reductoisomerase inhibitors, with IC50 in the nM range, much better than fosmidomycin, the reference compound. They also showed an enhanced antimicrobial activity against E. coli on Petri dishes in comparison with the corresponding phosphates and the non-fluorinated phosphonate.
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Base de dados:
MEDLINE
Assunto principal:
Fosfomicina
/
Ácidos Hidroxâmicos
/
Antibacterianos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article