Autophagy in major human diseases.
EMBO J
; 40(19): e108863, 2021 10 01.
Article
em En
| MEDLINE
| ID: mdl-34459017
ABSTRACT
Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.
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Base de dados:
MEDLINE
Assunto principal:
Autofagia
/
Suscetibilidade a Doenças
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article