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Autophagy in major human diseases.
Klionsky, Daniel J; Petroni, Giulia; Amaravadi, Ravi K; Baehrecke, Eric H; Ballabio, Andrea; Boya, Patricia; Bravo-San Pedro, José Manuel; Cadwell, Ken; Cecconi, Francesco; Choi, Augustine M K; Choi, Mary E; Chu, Charleen T; Codogno, Patrice; Colombo, Maria Isabel; Cuervo, Ana Maria; Deretic, Vojo; Dikic, Ivan; Elazar, Zvulun; Eskelinen, Eeva-Liisa; Fimia, Gian Maria; Gewirtz, David A; Green, Douglas R; Hansen, Malene; Jäättelä, Marja; Johansen, Terje; Juhász, Gábor; Karantza, Vassiliki; Kraft, Claudine; Kroemer, Guido; Ktistakis, Nicholas T; Kumar, Sharad; Lopez-Otin, Carlos; Macleod, Kay F; Madeo, Frank; Martinez, Jennifer; Meléndez, Alicia; Mizushima, Noboru; Münz, Christian; Penninger, Josef M; Perera, Rushika M; Piacentini, Mauro; Reggiori, Fulvio; Rubinsztein, David C; Ryan, Kevin M; Sadoshima, Junichi; Santambrogio, Laura; Scorrano, Luca; Simon, Hans-Uwe; Simon, Anna Katharina; Simonsen, Anne.
Afiliação
  • Klionsky DJ; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
  • Petroni G; Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
  • Amaravadi RK; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Baehrecke EH; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
  • Ballabio A; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA.
  • Boya P; Telethon Institute of Genetics and Medicine, Pozzuoli, Italy.
  • Bravo-San Pedro JM; Department of Translational Medical Sciences, Section of Pediatrics, Federico II University, Naples, Italy.
  • Cadwell K; Department of Molecular and Human Genetics, Baylor College of Medicine, and Jan and Dan Duncan Neurological Research Institute, Texas Children Hospital, Houston, TX, USA.
  • Cecconi F; Margarita Salas Center for Biological Research, Spanish National Research Council, Madrid, Spain.
  • Choi AMK; Faculty of Medicine, Department Section of Physiology, Complutense University of Madrid, Madrid, Spain.
  • Choi ME; Center for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain.
  • Chu CT; Kimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine, New York, NY, USA.
  • Codogno P; Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA.
  • Colombo MI; Division of Gastroenterology and Hepatology, Department of Medicine, New York University Langone Health, New York, NY, USA.
  • Cuervo AM; Cell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center, Copenhagen, Denmark.
  • Deretic V; Department of Pediatric Onco-Hematology and Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
  • Dikic I; Department of Biology, University of Rome 'Tor Vergata', Rome, Italy.
  • Elazar Z; Division of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Eskelinen EL; New York-Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA.
  • Fimia GM; New York-Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA.
  • Gewirtz DA; Division of Nephrology and Hypertension, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Green DR; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Hansen M; Institut Necker-Enfants Malades, INSERM U1151-CNRS UMR 8253, Paris, France.
  • Jäättelä M; Université de Paris, Paris, France.
  • Johansen T; Laboratorio de Mecanismos Moleculares Implicados en el Tráfico Vesicular y la Autofagia-Instituto de Histología y Embriología (IHEM)-Universidad Nacional de Cuyo, CONICET- Facultad de Ciencias Médicas, Mendoza, Argentina.
  • Juhász G; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.
  • Karantza V; Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.
  • Kraft C; Autophagy Inflammation and Metabolism (AIM, Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
  • Kroemer G; Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
  • Ktistakis NT; Institute of Biochemistry II, School of Medicine, Goethe University, Frankfurt, Frankfurt am Main, Germany.
  • Kumar S; Buchmann Institute for Molecular Life Sciences, Goethe University, Frankfurt, Frankfurt am Main, Germany.
  • Lopez-Otin C; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel.
  • Macleod KF; Institute of Biomedicine, University of Turku, Turku, Finland.
  • Madeo F; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
  • Martinez J; Department of Epidemiology, Preclinical Research, and Advanced Diagnostics, National Institute for Infectious Diseases 'L. Spallanzani' IRCCS, Rome, Italy.
  • Meléndez A; Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
  • Mizushima N; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Münz C; Sanford Burnham Prebys Medical Discovery Institute, Program of Development, Aging, and Regeneration, La Jolla, CA, USA.
  • Penninger JM; Cell Death and Metabolism, Center for Autophagy, Recycling & Disease, Danish Cancer Society Research Center, Copenhagen, Denmark.
  • Perera RM; Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Piacentini M; Department of Medical Biology, Molecular Cancer Research Group, University of Tromsø-The Arctic University of Norway, Tromsø, Norway.
  • Reggiori F; Institute of Genetics, Biological Research Center, Szeged, Hungary.
  • Rubinsztein DC; Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary.
  • Ryan KM; Merck & Co., Inc., Kenilworth, NJ, USA.
  • Sadoshima J; Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Santambrogio L; CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.
  • Scorrano L; Centre de Recherche des Cordeliers, Equipe Labellisée par la Ligue Contre le Cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France.
  • Simon HU; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France.
  • Simon AK; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.
  • Simonsen A; Suzhou Institute for Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China.
EMBO J ; 40(19): e108863, 2021 10 01.
Article em En | MEDLINE | ID: mdl-34459017
ABSTRACT
Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Suscetibilidade a Doenças Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Suscetibilidade a Doenças Idioma: En Ano de publicação: 2021 Tipo de documento: Article