Cerebral Amyloid Angiopathy in a Mouse Model of Alzheimer's Disease Associates with Upregulated Angiopoietin and Downregulated Hypoxia-Inducible Factor.

Skaaraas, Gry H E Syverstad; Melbye, Christoffer; Puchades, Maja A; Leung, Doreen Siu Yi; Jacobsen, Øyvind; Rao, Shreyas B; Ottersen, Ole Petter; Leergaard, Trygve B; Torp, Reidun

Skaaraas, Gry H E Syverstad; Melbye, Christoffer; Puchades, Maja A; Leung, Doreen Siu Yi; Jacobsen, Øyvind; Rao, Shreyas B; Ottersen, Ole Petter; Leergaard, Trygve B; Torp, Reidun.

Afiliação

Skaaraas GHES; Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Melbye C; Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Puchades MA; Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Leung DSY; Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Jacobsen Ø; Department of Pharmacy, University of Oslo, Oslo, Norway.
Rao SB; Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Ottersen OP; Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Leergaard TB; Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Torp R; Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

J Alzheimers Dis ; 83(4): 1651-1663, 2021.

Article em En | MEDLINE | ID: mdl-34459401

Assuntos

Doença de Alzheimer/patologia; Angiopoietinas; Angiopatia Amiloide Cerebral/patologia; Hipóxia/metabolismo; Camundongos Transgênicos; Regulação para Cima; Precursor de Proteína beta-Amiloide/genética; Animais; Encéfalo/patologia; Modelos Animais de Doenças; Camundongos; Pericitos/patologia; Placa Amiloide/patologia

Palavras-chave

Alzheimer's disease; HIF1a; VEGF; amyloid-ß; angiogenesis; cerebral amyloid angiopathy; mouse model; pericytes

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Camundongos Transgênicos / Regulação para Cima / Angiopatia Amiloide Cerebral / Angiopoietinas / Doença de Alzheimer / Hipóxia Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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