Genetic variability affects the response of skeletal muscle to disuse.
J Musculoskelet Neuronal Interact
; 21(3): 387-396, 2021 09 01.
Article
em En
| MEDLINE
| ID: mdl-34465678
ABSTRACT
OBJECTIVE:
To examine whether genetic variability plays a role in skeletal muscle response to disuse.METHODS:
We examined skeletal muscle response to disuse in five different strains of mice CAST/EiJ, NOD/ShiLtJ, NZO/HILtJ, 129S1/SvImJ and A/J. Mice had one limb immobilized by a cast for three weeks.RESULTS:
Response to immobilization was dependent on the strain of mice. Skeletal muscle mass/body weight was decreased by immobilization in all strains except 1291/SvImJ. Immobilization decreased absolute skeletal muscle mass in quadriceps and gastrocnemius in NOD/ShiltJ and NZO/HILtJ mice. Three weeks of immobilization resulted in an increase in quadriceps levels of atrogenes in CAST/EiJ. Immobilization resulted in an increase in quadriceps and gastrocnemius levels of Myh4 in CAST/EiJ. A similar trend was observed for Myh7 in gastrocnemius muscle. Immobilization resulted in a decrease of the p-p70S6K1/total p706SK1 ratio in quadriceps of NOD/ShiLtJ mice and the gastrocnemius of A/J mice. Immobilization did not affect the p-4EBP1/total 4EBP1 ratio in quadriceps of any of the strains examined. However, the p-4EBP1/total 4EBP1 ratio in gastrocnemius was greater in immobilized, relative to control, limbs in CAST/EiJ mice.CONCLUSION:
Genetic variability affects the response of skeletal muscle to disuse.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Músculo Esquelético
/
Músculo Quadríceps
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article