Polyclonal alpaca antibodies protect against hantavirus pulmonary syndrome in a lethal Syrian hamster model.
Sci Rep
; 11(1): 17440, 2021 08 31.
Article
em En
| MEDLINE
| ID: mdl-34465819
ABSTRACT
The use of antibody-based therapies for the treatment of high consequence viral pathogens has gained interest over the last fifteen years. Here, we sought to evaluate the use of unique camelid-based IgG antibodies to prevent lethal hantavirus pulmonary syndrome (HPS) in Syrian hamsters. Using purified, polyclonal IgG antibodies generated in DNA-immunized alpacas, we demonstrate that post-exposure treatments reduced viral burdens and organ-specific pathology associated with lethal HPS. Antibody treated animals did not exhibit signs of disease and were completely protected. The unique structures and properties, particularly the reduced size, distinct paratope formation and increased solubility of camelid antibodies, in combination with this study support further pre-clinical evaluation of heavy-chain only antibodies for treatment of severe respiratory diseases, including HPS.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina G
/
Glicoproteínas
/
Orthohantavírus
/
Síndrome Pulmonar por Hantavirus
/
Infecções por Hantavirus
/
Modelos Animais de Doenças
/
Anticorpos Antivirais
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article