Relations of heart-type and brain-type fatty acid-binding proteins with postoperative cognitive dysfunction in elderly patients undergoing spinal surgery.
Rev Assoc Med Bras (1992)
; 67(3): 390-394, 2021 Mar.
Article
em En
| MEDLINE
| ID: mdl-34468603
ABSTRACT
OBJECTIVE:
The aim of this study is to analyze the relations of heart-type fatty acid-binding protein (H-FABP) and brain-type fatty acid-binding protein (B-FABP) with postoperative cognitive dysfunction (POCD) in elderly patients undergoing spinal surgery.METHODS:
One hundred and twenty-five patients who underwent spinal surgery were enrolled in this study. According to whether patients had POCD within 5 days after surgery, the participants were divided into POCD group and non-POCD group. Before surgery and 6 h after surgery, the serum H-FABP and B-FABP contents were detected.RESULTS:
There were 33 (26.4%) patients in POCD group, and 92 (73.60%) patients in non-POCD group. After surgery, the serum H-FABP and B-FABP contents in POCD group were significantly higher than those before surgery, respectively (p<0.05), and those in non-POCD group were significantly lower than those before surgery, respectively (p<0.05). After surgery, the serum H-FABP and B-FABP contents in POCD group were significantly higher than those in non-POCD group, respectively (p<0.05).CONCLUSION:
The serum H-FABP and B-FABP contents are positively related to the occurrence of POCD in elderly patients undergoing spinal surgery.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Coluna Vertebral
/
Disfunção Cognitiva
/
Complicações Cognitivas Pós-Operatórias
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article