Lobeglitazone attenuates fibrosis in corneal fibroblasts by interrupting TGF-beta-mediated Smad signaling.

Nuwormegbe, Selikem; Park, Na-Young; Kim, Sun Woong

Nuwormegbe, Selikem; Park, Na-Young; Kim, Sun Woong.

Afiliação

Nuwormegbe S; Department of Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju, Ilsan-ro, Gangwon-do, 26426, Republic of Korea.
Park NY; Department of Ophthalmology, Wonju College of Medicine, Yonsei University, Wonju, Ilsan-ro, Gangwon-do, 26426, Republic of Korea.
Kim SW; Department of Ophthalmology, Wonju College of Medicine, Yonsei University, Wonju, Ilsan-ro, Gangwon-do, 26426, Republic of Korea. eyedockim@yonsei.ac.kr.

Graefes Arch Clin Exp Ophthalmol ; 260(1): 149-162, 2022 Jan.

Article em En | MEDLINE | ID: mdl-34468828

Assuntos

Fibroblastos/patologia; Pirimidinas; Proteínas Smad; Tiazolidinedionas; Fator de Crescimento Transformador beta1; Células Cultivadas; Diabetes Mellitus Tipo 2; Fibrose; Humanos; Pirimidinas/farmacologia; Transdução de Sinais; Tiazolidinedionas/farmacologia

Palavras-chave

Corneal fibroblasts; Fibrosis; Lobeglitazone; TGF-ß1; Thiazolidinediones

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Tiazolidinedionas / Proteínas Smad / Fator de Crescimento Transformador beta1 / Fibroblastos Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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