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HCF2Se/HCF2S Installation by Tandem Substitutions from Alkyl Bromides.
Zhang, Min; Lin, Jin-Hong; Xiao, Ji-Chang.
Afiliação
  • Zhang M; Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
  • Lin JH; Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
  • Xiao JC; Department of Chemistry, Innovative Drug Research Center, Shanghai University, Shanghai 200444, China.
J Org Chem ; 86(18): 13153-13159, 2021 09 17.
Article em En | MEDLINE | ID: mdl-34476948
ABSTRACT
Herein we describe an efficient construction of HCF2Se and HCF2S groups by tandem substitutions between alkyl bromides and a reagent system consisting of MSeCN (or MSCN) and Ph3P+CF2H Br-. The tandem process occurs via the first nucleophilic substitution of alkyl bromides by -SeCN (or -SCN) and the subsequent nucleophilic difluoromethylation.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Brometos Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Brometos Idioma: En Ano de publicação: 2021 Tipo de documento: Article