Impact of heat on biological concentrations of toluene and acetone resulting from exposure by inhalation: A pilot study.
Environ Toxicol Pharmacol
; 88: 103737, 2021 Nov.
Article
em En
| MEDLINE
| ID: mdl-34481063
ABSTRACT
Climatic conditions raise new concerns about the potential impact of heat on the absorption and kinetics of certain chemicals. The impact of 3 temperatures (21, 25 and 30 °C WBGT) on the toxicokinetics of toluene and acetone was therefore evaluated in five human subjects during controlled exposures in an inhalation chamber. Biological samples were collected and analyzed by GC-MS/MS. Increases between 4 and 85 % were observed for solvents concentrations in blood (30 vs 21 °C) while decreases in urine samples for acetone and o-cresol were measured at the end of the exposure period (4 h). Mean blood concentrations at 4 h are well correlated with temperature. Results suggest an increased absorption and/or a decreased elimination of volatile chemicals in the presence of heat. Higher increases of blood chemical concentrations were observed in heavier individuals. Further studies should include physiologically based toxicokinetic models to help in better understanding the mechanisms involved and their respective contribution.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Acetona
/
Solventes
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Tolueno
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Temperatura Alta
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article