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USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradation of NLRP3.
Cai, Baoshan; Zhao, Jian; Zhang, Yuling; Liu, Yaxing; Ma, Chunhong; Yi, Fan; Zheng, Yi; Zhang, Lei; Chen, Tian; Liu, Huiqing; Liu, Bingyu; Gao, Chengjiang.
Afiliação
  • Cai B; Key Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, School of Biomedical Sciences, Shandong University, Jinan, China.
  • Zhao J; Key Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, School of Biomedical Sciences, Shandong University, Jinan, China.
  • Zhang Y; Key Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, School of Biomedical Sciences, Shandong University, Jinan, China.
  • Liu Y; Key Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, School of Biomedical Sciences, Shandong University, Jinan, China.
  • Ma C; Key Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, School of Biomedical Sciences, Shandong University, Jinan, China.
  • Yi F; Department of Pharmacology, School of Biomedical Sciences, Shandong University, Jinan, China.
  • Zheng Y; Key Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, School of Biomedical Sciences, Shandong University, Jinan, China.
  • Zhang L; Key Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, School of Biomedical Sciences, Shandong University, Jinan, China.
  • Chen T; Department of Pathogenic Biology, School of Biomedical Sciences, Shandong University, Jinan, China.
  • Liu H; Department of Pharmacology, School of Biomedical Sciences, Shandong University, Jinan, China.
  • Liu B; Key Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, School of Biomedical Sciences, Shandong University, Jinan, China.
  • Gao C; Key Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, School of Biomedical Sciences, Shandong University, Jinan, China.
Autophagy ; 18(5): 990-1004, 2022 05.
Article em En | MEDLINE | ID: mdl-34486483
ABSTRACT
ABBREVIATIONS 3-MA 3-methyladenine; AIM2 absent in melanoma 2; ATG5 autophagy related 5; BafA1 bafilomycin A1; CASP1 caspase 1; CHX cycloheximide; Co-IP co-immunoprecipitation; CQ chloroquine; DUBs deubiquitinases; IL1B/IL-1ß interleukin 1 beta; LAMP1 lysosomal associated membrane protein 1; LPS lipopolysaccharide; MARCHF7/MARCH7 membrane associated RING-CH-type finger 7; NFKB/NF-κB nuclear factor kappa B; Nig. nigericin; NLRC4 NLR family CARD domain containing 4; NLRP3 NLR family pyrin domain containing 3; PECs peritoneal exudate cells; PMN polymorphonuclear; PMs peritoneal macrophages; PYCARD/ASC PYD and CARD domain containing; TLRs toll like receptors; TNF/TNF-α tumor necrosis factor; Ub ubiquitin; USP5 ubiquitin specific peptidase 5; WT wild type.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inflamassomos / Proteína 3 que Contém Domínio de Pirina da Família NLR Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inflamassomos / Proteína 3 que Contém Domínio de Pirina da Família NLR Idioma: En Ano de publicação: 2022 Tipo de documento: Article