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A mitochondrial-metabolism-regulatable carrier-free nanodrug to amplify the sensitivity of photothermal therapy.
Du, Qian; Qin, Xiaohan; Zhang, Mengzhu; Zhao, Zhipeng; Li, Qian; Ren, Xiaomeng; Wang, Ningning; Luan, Yuxia.
Afiliação
  • Du Q; Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China. yuxialuan@sdu.edu.cn.
  • Qin X; Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China. yuxialuan@sdu.edu.cn.
  • Zhang M; Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China. yuxialuan@sdu.edu.cn.
  • Zhao Z; Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China. yuxialuan@sdu.edu.cn.
  • Li Q; Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China. yuxialuan@sdu.edu.cn.
  • Ren X; Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China. yuxialuan@sdu.edu.cn.
  • Wang N; Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China. yuxialuan@sdu.edu.cn.
  • Luan Y; Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China. yuxialuan@sdu.edu.cn.
Chem Commun (Camb) ; 57(71): 8993-8996, 2021 Sep 06.
Article em En | MEDLINE | ID: mdl-34486606
ABSTRACT
The oxidative phosphorylation inhibitor atovaquone (ATO) and the photosensitizer new indocyanine green (IR820) were self-assembled into carrier-free nanodrugs (IR820/ATO NPs) to achieve superior photothermal therapy (PTT), offering an attractive mitochondrial metabolism-regulatable approach for breast cancer treatment, where adenosine triphosphate (ATP) was downregulated along with downregulating the expression of heat shock proteins (HSPs) to amplify the sensitivity of PTT.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Fármacos Fotossensibilizantes / Atovaquona / Nanopartículas / Verde de Indocianina / Antineoplásicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Fármacos Fotossensibilizantes / Atovaquona / Nanopartículas / Verde de Indocianina / Antineoplásicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article