A universal pocket in fatty acyl-AMP ligases ensures redirection of fatty acid pool away from coenzyme A-based activation.

Patil, Gajanan S; Kinatukara, Priyadarshan; Mondal, Sudipta; Shambhavi, Sakshi; Patel, Ketan D; Pramanik, Surabhi; Dubey, Noopur; Narasimhan, Subhash; Madduri, Murali Krishna; Pal, Biswajit; Gokhale, Rajesh S; Sankaranarayanan, Rajan

Patil, Gajanan S; Kinatukara, Priyadarshan; Mondal, Sudipta; Shambhavi, Sakshi; Patel, Ketan D; Pramanik, Surabhi; Dubey, Noopur; Narasimhan, Subhash; Madduri, Murali Krishna; Pal, Biswajit; Gokhale, Rajesh S; Sankaranarayanan, Rajan.

Afiliação

Patil GS; CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
Kinatukara P; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
Mondal S; CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
Shambhavi S; CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
Patel KD; CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
Pramanik S; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
Dubey N; CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
Narasimhan S; CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
Madduri MK; CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
Pal B; CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
Gokhale RS; CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
Sankaranarayanan R; CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.

Elife ; 102021 09 07.

Article em En | MEDLINE | ID: mdl-34490847

Assuntos

Acil Coenzima A/metabolismo; Monofosfato de Adenosina/metabolismo; Proteínas de Bactérias/metabolismo; Ácidos Graxos/metabolismo; Ligases/metabolismo; Proteínas de Bactérias/química; Proteínas de Bactérias/genética; Sítios de Ligação; Ligases/química; Ligases/genética; Modelos Moleculares; Mutação; Ligação Proteica; Conformação Proteica; Relação Estrutura-Atividade

Palavras-chave

E. coli; acyl carrier protein; biochemistry; chemical biology; coenzyme A; fatty acids; fatty acyl-AMP ligases; nonribosomal peptide synthetases; polyketide synthases

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Acil Coenzima A / Monofosfato de Adenosina / Ácidos Graxos / Ligases Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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