Glutamine synthetase regulation by dexamethasone, RU486, and compound A in astrocytes derived from aged mouse cerebral hemispheres is mediated via glucocorticoid receptor.

Kazazoglou, Theodosia; Panagiotou, Christina; Mihailidou, Chrysovalantou; Kokkinopoulou, Ioanna; Papadopoulou, Anna; Moutsatsou, Paraskevi

Kazazoglou, Theodosia; Panagiotou, Christina; Mihailidou, Chrysovalantou; Kokkinopoulou, Ioanna; Papadopoulou, Anna; Moutsatsou, Paraskevi.

Afiliação

Kazazoglou T; 1st Department of Psychiatry, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Panagiotou C; Cellular and Molecular Neurobiology Laboratory, University Mental Health, Neurosciences and Precision Medicine Research Institute "Costas Stefanis" (UMHRI), Athens, Greece.
Mihailidou C; Department of Clinical Biochemistry, Medical School, National and Kapodistrian University of Athens, University General Hospital "ATTIKON", Rimini 1 str, Haidari, 12462, Athens, Greece.
Kokkinopoulou I; Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Papadopoulou A; Department of Clinical Biochemistry, Medical School, National and Kapodistrian University of Athens, University General Hospital "ATTIKON", Rimini 1 str, Haidari, 12462, Athens, Greece.
Moutsatsou P; Department of Clinical Biochemistry, Medical School, National and Kapodistrian University of Athens, University General Hospital "ATTIKON", Rimini 1 str, Haidari, 12462, Athens, Greece.

Mol Cell Biochem ; 476(12): 4471-4485, 2021 Dec.

Article em En | MEDLINE | ID: mdl-34491525

Assuntos

Astrócitos/metabolismo; Cérebro/metabolismo; Glutamato-Amônia Ligase/metabolismo; Receptores de Glucocorticoides/metabolismo; Acetatos/farmacologia; Fatores Etários; Animais; Anti-Inflamatórios/farmacologia; Anti-Inflamatórios não Esteroides/farmacologia; Astrócitos/efeitos dos fármacos; Células Cultivadas; Cérebro/efeitos dos fármacos; Cérebro/patologia; Dexametasona/farmacologia; Antagonistas de Hormônios/farmacologia; Camundongos; Mifepristona/farmacologia; Tiramina/análogos & derivados; Tiramina/farmacologia

Palavras-chave

Compound A; GR modulators; Glucocorticoid receptor; Glutamine synthetase; MACH astrocytes; RU486

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Glucocorticoides / Astrócitos / Cérebro / Glutamato-Amônia Ligase Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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