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A scalable Drosophila assay for clinical interpretation of human PTEN variants in suppression of PI3K/AKT induced cellular proliferation.
Ganguly, Payel; Madonsela, Landiso; Chao, Jesse T; Loewen, Christopher J R; O'Connor, Timothy P; Verheyen, Esther M; Allan, Douglas W.
Afiliação
  • Ganguly P; Department of Cellular and Physiological Sciences, Life Sciences Institute, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.
  • Madonsela L; Department of Molecular Biology and Biochemistry, Centre for Cell Biology, Development and Disease, Simon Fraser University, Burnaby, British Columbia, Canada.
  • Chao JT; Department of Cellular and Physiological Sciences, Life Sciences Institute, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.
  • Loewen CJR; Department of Cellular and Physiological Sciences, Life Sciences Institute, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.
  • O'Connor TP; Department of Cellular and Physiological Sciences, Life Sciences Institute, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.
  • Verheyen EM; Department of Molecular Biology and Biochemistry, Centre for Cell Biology, Development and Disease, Simon Fraser University, Burnaby, British Columbia, Canada.
  • Allan DW; Department of Cellular and Physiological Sciences, Life Sciences Institute, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.
PLoS Genet ; 17(9): e1009774, 2021 09.
Article em En | MEDLINE | ID: mdl-34492006
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfatidilinositol 3-Quinases / Proliferação de Células / Drosophila melanogaster / PTEN Fosfo-Hidrolase / Proteínas Proto-Oncogênicas c-akt Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfatidilinositol 3-Quinases / Proliferação de Células / Drosophila melanogaster / PTEN Fosfo-Hidrolase / Proteínas Proto-Oncogênicas c-akt Idioma: En Ano de publicação: 2021 Tipo de documento: Article