The active fragments of ghrelin cross the blood-brain barrier and enter the brain to produce antinociceptive effects after systemic administration.

Fan, Bao-Wei; Liu, Yong-Ling; Zhu, Gui-Xian; Wu, Bing; Zhang, Min-Min; Deng, Qing; Wang, Jing-Lei; Chen, Jia-Xiang; Han, Ren-Wen; Wei, Jie

Fan, Bao-Wei; Liu, Yong-Ling; Zhu, Gui-Xian; Wu, Bing; Zhang, Min-Min; Deng, Qing; Wang, Jing-Lei; Chen, Jia-Xiang; Han, Ren-Wen; Wei, Jie.

Afiliação

Fan BW; Department of Physiology, Medical College of Nanchang University, Bayi Road 461, Nanchang, Jiangxi, 330006, China.
Liu YL; Department of Physiology, Medical College of Nanchang University, Bayi Road 461, Nanchang, Jiangxi, 330006, China.
Zhu GX; Department of Physiology, Medical College of Nanchang University, Bayi Road 461, Nanchang, Jiangxi, 330006, China.
Wu B; Department of Physiology, Medical College of Nanchang University, Bayi Road 461, Nanchang, Jiangxi, 330006, China.
Zhang MM; Department of Physiology, Medical College of Nanchang University, Bayi Road 461, Nanchang, Jiangxi, 330006, China.
Deng Q; Department of Physiology, Medical College of Nanchang University, Bayi Road 461, Nanchang, Jiangxi, 330006, China.
Wang JL; Department of Physiology, Medical College of Nanchang University, Bayi Road 461, Nanchang, Jiangxi, 330006, China.
Chen JX; Department of Physiology, Medical College of Nanchang University, Bayi Road 461, Nanchang, Jiangxi, 330006, China.
Han RW; Laboratory of Fear and Anxiety Disorders, Institute of Life Science, Nanchang University, Nanchang, China.
Wei J; Department of Physiology, Medical College of Nanchang University, Bayi Road 461, Nanchang, Jiangxi, 330006, China.

Can J Physiol Pharmacol ; 99(10): 1057-1068, 2021 Oct.

Article em En | MEDLINE | ID: mdl-34492212

Assuntos

Dor Aguda/tratamento farmacológico; Analgésicos/farmacologia; Barreira Hematoencefálica/metabolismo; Encéfalo/metabolismo; Grelina/administração & dosagem; Grelina/farmacocinética; Temperatura Alta/efeitos adversos; Dor Aguda/etiologia; Dor Aguda/metabolismo; Dor Aguda/patologia; Animais; Animais não Endogâmicos; Barreira Hematoencefálica/efeitos dos fármacos; Encéfalo/efeitos dos fármacos; Grelina/farmacologia; Masculino; Camundongos; Antagonistas de Entorpecentes/farmacologia; Receptores de Grelina/antagonistas & inibidores; Receptores de Grelina/metabolismo; Receptores Opioides/química; Receptores Opioides/metabolismo

Palavras-chave

G; GHS-R1α; antinociception; barrière hémo-encéphalique; bloodbrain barrier; opioid receptors; récepteurs opioïdes

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Barreira Hematoencefálica / Grelina / Dor Aguda / Temperatura Alta / Analgésicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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