Neuroprotective strategies of cerebrolysin for the treatment of infants with neonatal hypoxic-ischemic encephalopathy.
Acta Neurol Belg
; 121(6): 1401-1406, 2021 Dec.
Article
em En
| MEDLINE
| ID: mdl-34494216
ABSTRACT
BACKGROUND:
Perinatal asphyxia (PA) is a devastating neonatal condition characterized by a lack of oxygen supporting the organ systems. PA can lead to hypoxic-ischemic encephalopathy (HIE), a brain dysfunction due to oxygen deprivation with a complex neurological sequela. The pathophysiology of HIE and PA is not entirely understood, with therapeutic hypothermia being the standard treatment with only limited value. However, alternative neuroprotective therapies can be a potential treatment modality.METHODS:
In this review, we will characterize the biochemical mechanisms of PA and HIE, while also giving insight into cerebrolysin, a neuroprotective treatment used for HIE and PA.RESULTS:
We found that cerebrolysin has up to 6-month treatment window post-ischemic insult. Cerebrolysin injections of 0.1 ml/kg of body weight twice per week were found to provide gross motor and speech deficit improvement.CONCLUSION:
Our literature search emphasizes the positive effects of cerebrolysin for general improvement outcomes. Nevertheless, biomarker establishment is warranted to improve patient outcomes.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Asfixia Neonatal
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Fármacos Neuroprotetores
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Hipóxia-Isquemia Encefálica
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Aminoácidos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article