Secreted matrix metalloproteinase-14 is a predictor for antifibrotic effect of IC-2-engineered mesenchymal stem cell sheets on liver fibrosis in mice.

Fukushima, Kenji; Itaba, Noriko; Kono, Yohei; Okazaki, Shizuma; Enokida, Shinpei; Kuranobu, Naomi; Murakami, Jun; Enokida, Makoto; Nagashima, Hideki; Kanzaki, Susumu; Namba, Noriyuki; Shiota, Goshi

Fukushima, Kenji; Itaba, Noriko; Kono, Yohei; Okazaki, Shizuma; Enokida, Shinpei; Kuranobu, Naomi; Murakami, Jun; Enokida, Makoto; Nagashima, Hideki; Kanzaki, Susumu; Namba, Noriyuki; Shiota, Goshi.

Afiliação

Fukushima K; Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, Tottori, 683-8504, Japan.
Itaba N; Division of Medical Genetics and Regenerative Medicine, Department of Genomic Medicine and Regenerative Therapy, School of Medicine, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, Tottori, 683-8503, Japan.
Kono Y; Division of Medical Genetics and Regenerative Medicine, Department of Genomic Medicine and Regenerative Therapy, School of Medicine, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, Tottori, 683-8503, Japan.
Okazaki S; Division of Medical Genetics and Regenerative Medicine, Department of Genomic Medicine and Regenerative Therapy, School of Medicine, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, Tottori, 683-8503, Japan.
Enokida S; Division of Orthopedic Surgery, Department of Sensory and Motor Organs, School of Medicine, Faculty of Medicine, Tottori University, Yonago, 683-8504, Japan.
Kuranobu N; Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, Tottori, 683-8504, Japan.
Murakami J; Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, Tottori, 683-8504, Japan.
Enokida M; Division of Orthopedic Surgery, Department of Sensory and Motor Organs, School of Medicine, Faculty of Medicine, Tottori University, Yonago, 683-8504, Japan.
Nagashima H; Division of Orthopedic Surgery, Department of Sensory and Motor Organs, School of Medicine, Faculty of Medicine, Tottori University, Yonago, 683-8504, Japan.
Kanzaki S; Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, Tottori, 683-8504, Japan.
Namba N; Asahigawaso Rehabilitation & Medical Center, Okayama, 703-8555, Japan.
Shiota G; Division of Pediatrics and Perinatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, Tottori, 683-8504, Japan.

Regen Ther ; 18: 292-301, 2021 Dec.

Article em En | MEDLINE | ID: mdl-34504910

Palavras-chave

ALT, alanine aminotransferase; AST, aspartate aminotransferase; BM-MSCs, bone marrow-derived mesenchymal stem cells; C3, complement C3; CCl4, carbon tetrachloride; DMSO, dimethyl sulfoxide; EDTA, ethylenediamine tetra-acetic acid; FACS, Fluorescence-activated cell sorter; FALD, fontan-associated liver disease; GAPDH, Glyceraldehyde 3-phosphate dehydrogenase; HCC, hepatic cellular carcinoma; HLA, human leukocyte antigen; HSCs, hepatic stellate cells; Hepatic cell sheets; IgG, immunoglobulin G; LC, liver cirrhosis; MMP-14, matrix metalloproteinase; MSCs, mesenchymal stem cells; Matrix metalloproteinase-14; Mesenchymal stem cells; Wnt/ß-catenin signal inhibitor; chronic liver injury; hBM-MNCs, human bone marrow mononuclear cells; iPS cells, induced pluripotent stem cells; αSMA, α-smooth muscle actin

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article