Diagnostic and prognostic predictive values of circulating sTREM-1 in sepsis: A meta-analysis.
Infect Genet Evol
; 96: 105074, 2021 12.
Article
em En
| MEDLINE
| ID: mdl-34506956
ABSTRACT
BACKGROUND:
With the increasing studies regarding the diagnostic value of soluble triggering receptor expressed on myeloid cells (sTREM)-1 in sepsis in recent years, it is essential to make an updated meta-analysis to explore the sepsis differentiation value of circulating sTREM-1 from systemic inflammatory response syndrome (SIRS). Recently, no meta-analysis was made to explore the prognostic predictive value of circulating sTREM-1 in sepsis. Thus, the present aimed to make meta-analyses to explore the diagnostic and prognostic predictive values of circulating sTREM-1 in sepsis.METHODS:
Articles published before March 2021 were searched in databases PubMed, Web of Science, EMBASE, Medline and Google Scholar. After a summary of sensitivity, specificity, positive likelihood ratios (PLR), negative likelihood ratios (NLR), and diagnostic odds ratio (DOR), the receive-operating characteristics (SROC) curve were performed to summarize true positive (TP) and false positive (FP) rates. Q test and I2 were used to explore heterogeneity between studies.RESULTS:
Circulating sTREM-1 showed a high sensitivity (0.85 (95% confidence interval (CI) 0.76-0.91)) and moderate specificity (0.79 (95% CI 0.70-0.86)) to differentiate sepsis from SIRS. The study showed a high sensitivity (0.80 (95% CI 0.66-0.89)) and moderate specificity (0.75 (95% CI 0.69-0.81)) to predict 28-day mortality in sepsis.CONCLUSION:
In conclusion, the present study suggested that circulating sTREM-1 showed diagnostic and prognostic predictive values in sepsis.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Sepse
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Técnicas de Diagnóstico Molecular
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Receptor Gatilho 1 Expresso em Células Mieloides
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article