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Elevated mycobacterium avium subsp. paratuberculosis (MAP) antibody titer in Japanese multiple sclerosis.
Hayashi, Fumie; Isobe, Noriko; Cossu, Davide; Yokoyama, Kazumasa; Sakoda, Ayako; Matsushita, Takuya; Hattori, Nobutaka; Kira, Jun-Ichi.
Afiliação
  • Hayashi F; Department of Neurology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Isobe N; Department of Neurology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Cossu D; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan; Department of Biomedical Sciences, Division of Microbiology and Virology, University of Sassari, Italy.
  • Yokoyama K; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
  • Sakoda A; Department of Neurology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Neurology, Brain and Nerve Center, Fukuoka Central Hospital, International University of Health and Welfare, Fukuoka, Japan.
  • Matsushita T; Department of Neurology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Hattori N; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
  • Kira JI; Department of Neurology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Neurology, Brain and Nerve Center, Fukuoka Central Hospital, International University of Health and Welfare, Fukuoka, Japan; Translational Neuroscience Center, Graduate School of Medicine,
J Neuroimmunol ; 360: 577701, 2021 11 15.
Article em En | MEDLINE | ID: mdl-34507015
ABSTRACT
To investigate whether antibody production against mycobacterium avium subsp. paratuberculosis (MAP) is related to clinical characteristics of multiple sclerosis (MS) and human leukocyte antigen (HLA) alleles, IgG antibody against three MAP peptides and two human peptides homologous to MAP were measured in sera from 103 MS patients and 50 healthy controls (HCs). MS patients had higher IgG levels against MAP2694295-303 (MAP2694-IgG) than HCs, while the other antibodies were comparable. Multivariate analysis demonstrated that higher MAP2694-IgG titers were associated with higher EDSS scores, but not with HLA alleles or dairy product consumption. Immune response against MAP may worsen MS disability.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imunoglobulina G / Mycobacterium avium subsp. paratuberculosis / Anticorpos Antibacterianos / Esclerose Múltipla Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imunoglobulina G / Mycobacterium avium subsp. paratuberculosis / Anticorpos Antibacterianos / Esclerose Múltipla Idioma: En Ano de publicação: 2021 Tipo de documento: Article