Elevated mycobacterium avium subsp. paratuberculosis (MAP) antibody titer in Japanese multiple sclerosis.
J Neuroimmunol
; 360: 577701, 2021 11 15.
Article
em En
| MEDLINE
| ID: mdl-34507015
ABSTRACT
To investigate whether antibody production against mycobacterium avium subsp. paratuberculosis (MAP) is related to clinical characteristics of multiple sclerosis (MS) and human leukocyte antigen (HLA) alleles, IgG antibody against three MAP peptides and two human peptides homologous to MAP were measured in sera from 103 MS patients and 50 healthy controls (HCs). MS patients had higher IgG levels against MAP2694295-303 (MAP2694-IgG) than HCs, while the other antibodies were comparable. Multivariate analysis demonstrated that higher MAP2694-IgG titers were associated with higher EDSS scores, but not with HLA alleles or dairy product consumption. Immune response against MAP may worsen MS disability.
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MEDLINE
Assunto principal:
Imunoglobulina G
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Mycobacterium avium subsp. paratuberculosis
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Anticorpos Antibacterianos
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Esclerose Múltipla
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article