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Suppressing mosquito populations with precision guided sterile males.
Li, Ming; Yang, Ting; Bui, Michelle; Gamez, Stephanie; Wise, Tyler; Kandul, Nikolay P; Liu, Junru; Alcantara, Lenissa; Lee, Haena; Edula, Jyotheeswara R; Raban, Robyn; Zhan, Yinpeng; Wang, Yijin; DeBeaubien, Nick; Chen, Jieyan; Sánchez C, Héctor M; Bennett, Jared B; Antoshechkin, Igor; Montell, Craig; Marshall, John M; Akbari, Omar S.
Afiliação
  • Li M; Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.
  • Yang T; Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.
  • Bui M; Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.
  • Gamez S; Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.
  • Wise T; Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.
  • Kandul NP; Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.
  • Liu J; Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.
  • Alcantara L; Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.
  • Lee H; Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.
  • Edula JR; Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.
  • Raban R; Tata Institute for Genetics and Society, La Jolla, CA, USA.
  • Zhan Y; Tata Institute for Genetics and Society (TIGS), TIGS Center at inStem, GKVK Campus, Bangalore, Karnataka, India.
  • Wang Y; Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.
  • DeBeaubien N; Department of Molecular, Cellular, and Developmental Biology and the Neuroscience Research Institute, University of California, Santa Barbara, CA, USA.
  • Chen J; Department of Molecular, Cellular, and Developmental Biology and the Neuroscience Research Institute, University of California, Santa Barbara, CA, USA.
  • Sánchez C HM; Department of Molecular, Cellular, and Developmental Biology and the Neuroscience Research Institute, University of California, Santa Barbara, CA, USA.
  • Bennett JB; Department of Molecular, Cellular, and Developmental Biology and the Neuroscience Research Institute, University of California, Santa Barbara, CA, USA.
  • Antoshechkin I; Divisions of Epidemiology & Biostatistics, School of Public Health, University of California, Berkeley, CA, USA.
  • Montell C; Divisions of Epidemiology & Biostatistics, School of Public Health, University of California, Berkeley, CA, USA.
  • Marshall JM; Biophysics Graduate Group, University of California, Berkeley, CA, USA.
  • Akbari OS; Division of Biology and Biological Engineering (BBE), California Institute of Technology, Pasadena, CA, USA.
Nat Commun ; 12(1): 5374, 2021 09 10.
Article em En | MEDLINE | ID: mdl-34508072
The mosquito Aedes aegypti is the principal vector for arboviruses including dengue/yellow fever, chikungunya, and Zika virus, infecting hundreds of millions of people annually. Unfortunately, traditional control methodologies are insufficient, so innovative control methods are needed. To complement existing measures, here we develop a molecular genetic control system termed precision-guided sterile insect technique (pgSIT) in Aedes aegypti. PgSIT uses a simple CRISPR-based approach to generate flightless females and sterile males that are deployable at any life stage. Supported by mathematical models, we empirically demonstrate that released pgSIT males can compete, suppress, and even eliminate mosquito populations. This platform technology could be used in the field, and adapted to many vectors, for controlling wild populations to curtail disease in a safe, confinable, and reversible manner.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Controle de Mosquitos / Aedes / Mosquitos Vetores / Infertilidade Masculina Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Controle de Mosquitos / Aedes / Mosquitos Vetores / Infertilidade Masculina Idioma: En Ano de publicação: 2021 Tipo de documento: Article