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Repeated Necrotizing Lymphadenitis with MEFV Gene Mutations.
Yamamura, Yuta; Furuichi, Kengo; Toyama, Tadashi; Oshima, Megumi; Ogura, Hisayuki; Sato, Koichi; Nakagawa, Shiori; Miyagawa, Taro; Kitajima, Shinji; Hara, Akinori; Iwata, Yasunori; Sakai, Norihiko; Shimizu, Miho; Ikeda, Hiroko; Toma, Tomoko; Takasawa, Kazuya; Yachie, Akihiro; Wada, Takashi.
Afiliação
  • Yamamura Y; Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
  • Furuichi K; Department of Nephrology, School of Medicine, Kanazawa Medical University, Japan.
  • Toyama T; Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
  • Oshima M; Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
  • Ogura H; Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
  • Sato K; Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
  • Nakagawa S; Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
  • Miyagawa T; Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
  • Kitajima S; Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
  • Hara A; Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
  • Iwata Y; Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
  • Sakai N; Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
  • Shimizu M; Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
  • Ikeda H; Department of Diagnostic Pathology, Kanazawa University Hospital, Japan.
  • Toma T; Department of Pediatrics, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
  • Takasawa K; Department of Internal Medicine, Public Central Hospital of Matto Ishikawa, Japan.
  • Yachie A; Division of Medical Safety, Kanazawa University, Japan.
  • Wada T; Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
Intern Med ; 61(7): 1105-1110, 2022 Apr 01.
Article em En | MEDLINE | ID: mdl-34511567
ABSTRACT
We herein report a 36-year-old man with repeated necrotizing lymphadenitis due to MEFV gene mutations. The patient's chief complaints were a fever and painful cervical lymphadenopathy. We diagnosed him with necrotizing lymphadenitis based on the pathological findings of the lymph nodes and the exclusion of other differential diseases. The same episode recurred four times. We speculated the involvement of autoinflammatory backgrounds and detected MEFV gene mutations of E148Q (homo), P369S, and R408Q. Considering the elevation of interleukin-18, these mutations probably played roles in the repeated necrotizing lymphadenitis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfadenite Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfadenite Idioma: En Ano de publicação: 2022 Tipo de documento: Article