A modified fluctuation assay reveals a natural mutator phenotype that drives mutation spectrum variation within <i>Saccharomyces cerevisiae</i>.

Jiang, Pengyao; Ollodart, Anja R; Sudhesh, Vidha; Herr, Alan J; Dunham, Maitreya J; Harris, Kelley

A modified fluctuation assay reveals a natural mutator phenotype that drives mutation spectrum variation within Saccharomyces cerevisiae.

Jiang, Pengyao; Ollodart, Anja R; Sudhesh, Vidha; Herr, Alan J; Dunham, Maitreya J; Harris, Kelley.

Afiliação

Jiang P; Department of Genome Sciences, University of Washington, Seattle, United States.
Ollodart AR; Department of Genome Sciences, University of Washington, Seattle, United States.
Sudhesh V; Molecular and Cellular Biology Program, University of Washington, Seattle, United States.
Herr AJ; Department of Genome Sciences, University of Washington, Seattle, United States.
Dunham MJ; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States.
Harris K; Department of Genome Sciences, University of Washington, Seattle, United States.

Elife ; 102021 09 15.

Article em En | MEDLINE | ID: mdl-34523420

Assuntos

Variação Genética; Mutação Puntual; Saccharomyces cerevisiae/genética; Alelos; Sistemas de Transporte de Aminoácidos Básicos/genética; Reparo do DNA; Diploide; Teste de Complementação Genética; Haploidia; Taxa de Mutação; Fenótipo; Saccharomyces cerevisiae/classificação; Proteínas de Saccharomyces cerevisiae/genética

Palavras-chave

S. cerevisiae; Saccharomyces cerevisiae; evolutionary biology; genetic variation; genetics; genomics; mutation rate; mutation spectrum; mutator phenotype; reporter assay

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Saccharomyces cerevisiae / Variação Genética / Mutação Puntual Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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