Do peripheral protein oligomers in neurodegenerative diseases shape T cell responses beyond the brain?
Immunology
; 164(2): 209-210, 2021 10.
Article
em En
| MEDLINE
| ID: mdl-34523728
ABSTRACT
Neurodegenerative diseases place a devastating burden on affected individuals and their families, and new treatments are desperately needed for these common immune-mediated inflammatory conditions. While large aggregates of abnormal proteins in the brain cause significant damage, it is becoming clear that smaller soluble protein aggregates can also contribute to disease, by both direct and indirect mechanisms. These soluble protein oligomers can be found in patients' serum. Here, we describe recent research that identifies effects of model oligomer molecules on peripheral blood T cells, therefore providing an additional mechanism by which neurodegeneration may be worsened through amplification of peripheral adaptive immune responses.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Linfócitos T
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Proteínas
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Doenças Neurodegenerativas
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article