Regioselective Monoborylation of Spirocyclobutenes.
Org Lett
; 23(19): 7434-7438, 2021 10 01.
Article
em En
| MEDLINE
| ID: mdl-34524833
ABSTRACT
We present a strategy for the synthesis of spirocyclic cyclobutanes with modulable exit vectors based on the regioselective monoborylation of spirocyclobutenes. Using an inexpensive copper salt and a commercially available bidentate phosphine, a broad variety of borylated spirocycles have been prepared with complete regiocontrol. The boryl moiety provides a synthetic handled for further functionalization, allowing access to a wide array of spirocyclic building blocks from a common intermediate.
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MEDLINE
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En
Ano de publicação:
2021
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Article