Luminescent Metal-Phenolic Networks for Multicolor Particle Labeling.
Angew Chem Int Ed Engl
; 60(47): 24968-24975, 2021 11 15.
Article
em En
| MEDLINE
| ID: mdl-34528750
ABSTRACT
The development of fluorescence labeling techniques has attracted widespread interest in various fields, including biomedical science as it can facilitate high-resolution imaging and the spatiotemporal understanding of various biological processes. We report a supramolecular fluorescence labeling strategy using luminescent metal-phenolic networks (MPNs) constructed from metal ions, phenolic ligands, and common and commercially available dyes. The rapid labeling process (<5â
min) produces ultrathin coatings (≈10â
nm) on diverse particles (e.g., organic, inorganic, and biological entities) with customized luminescence (e.g., red, blue, multichromatic, and white light) simply through the selection of fluorophores. The fluorescent coatings are stable at pH values from 1 to 8 and in complex biological media owing to the dominant π interactions between the dyes and MPNs. These coatings exhibit negligible cytotoxicity and their strong fluorescence is retained even when internalized into intracellular compartments. This strategy is expected to provide a versatile approach for fluorescence labeling with potential in diverse fields across the physical and life sciences.
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Base de dados:
MEDLINE
Assunto principal:
Fenóis
/
Cor
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Metais Pesados
/
Corantes Fluorescentes
/
Estruturas Metalorgânicas
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article