Serum amyloid A delivers retinol to intestinal myeloid cells to promote adaptive immunity.
Science
; 373(6561): eabf9232, 2021 Sep 17.
Article
em En
| MEDLINE
| ID: mdl-34529485
ABSTRACT
Vitamin A and its derivative retinol are essential for the development of intestinal adaptive immunity. Retinoic acid (RA)producing myeloid cells are central to this process, but how myeloid cells acquire retinol for conversion to RA is unknown. Here, we show that serum amyloid A (SAA) proteinsretinol-binding proteins induced in intestinal epithelial cells by the microbiotadeliver retinol to myeloid cells. We identify low-density lipoprotein (LDL) receptorrelated protein 1 (LRP1) as an SAA receptor that endocytoses SAA-retinol complexes and promotes retinol acquisition by RA-producing intestinal myeloid cells. Consequently, SAA and LRP1 are essential for vitamin Adependent immunity, including B and T cell homing to the intestine and immunoglobulin A production. Our findings identify a key mechanism by which vitamin A promotes intestinal immunity.
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Base de dados:
MEDLINE
Assunto principal:
Vitamina A
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Proteína Amiloide A Sérica
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Células Mieloides
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Proteína-1 Relacionada a Receptor de Lipoproteína de Baixa Densidade
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Imunidade Adaptativa
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Mucosa Intestinal
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Intestino Delgado
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article