Total Synthesis of Cochlearolâ
B via Intramolecular [2+2] Photocycloaddition.
Angew Chem Int Ed Engl
; 60(46): 24484-24487, 2021 11 08.
Article
em En
| MEDLINE
| ID: mdl-34533883
Herein, we describe the first total synthesis of cochlearolâ
B, a meroterpenoid natural product featuring a 4/5/6/6/6-fused pentacyclic structure. Key steps, oxidative cyclization and subsequent intramolecular [2+2] photocycloaddition, which constructed the pentacyclic structure in highly stereoselective manner, allowed efficient access to cochlearolâ
B with the longest linear sequence of 16 steps, and in 9 % overall yield. Single-crystal X-ray crystallographic analysis clearly confirmed the stereochemistry of cochlearolâ
B.
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1
Base de dados:
MEDLINE
Assunto principal:
Terpenos
/
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Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article