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Androgen-deprivation induced senescence in prostate cancer cells is permissive for the development of castration-resistance but susceptible to senolytic therapy.
Carpenter, Valerie; Saleh, Tareq; Min Lee, So; Murray, Graeme; Reed, Jason; Souers, Andrew; Faber, Anthony C; Harada, Hisashi; Gewirtz, David A.
Afiliação
  • Carpenter V; Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
  • Saleh T; Department of Basic Medical Sciences, Faculty of Medicine, The Hashemite University, Zarqa, Jordan.
  • Min Lee S; Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
  • Murray G; Department of Physics, Virginia Commonwealth University, Richmond, VA, USA.
  • Reed J; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA; Department of Physics, Virginia Commonwealth University, Richmond, VA, USA.
  • Souers A; AbbVie, 1 North Waukegan Road, North Chicago, IL, USA.
  • Faber AC; Philips Institute for Oral Health Research, School of Dentistry, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
  • Harada H; Philips Institute for Oral Health Research, School of Dentistry, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
  • Gewirtz DA; Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA. Electronic address: david.gewirtz@vcuhealth.org.
Biochem Pharmacol ; 193: 114765, 2021 11.
Article em En | MEDLINE | ID: mdl-34536356
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Neoplasias de Próstata Resistentes à Castração / Antineoplásicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Neoplasias de Próstata Resistentes à Castração / Antineoplásicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article